补体C5b-9复合物对小鼠抗红细胞免疫反应的抑制作用。
Suppression of the anti-erythrocyte immune response in mice by the C5b--9 complex of complement.
作者信息
Horn W, Opferkuch W, Podack E R
出版信息
Immunology. 1981 Jun;43(2):303-9.
The C5b--9 complex of complement associated with sheep erythrocyte membranes suppresses the immune response of mice to sheep erythrocytes as measured with the Jerne plaque technique. This type of immune suppression is independent of early complement components and antibody, and is mediated by both human and guinea-pig complement components. The degree of immune suppression correlates with the number of C5b--9 complexes per cell used for immunization: 21,000 C5b--9 complexes per erythrocyte lead to a 97% inhibition of the immune response in comparison to untreated erythrocytes. Inhibition requires the full assembly of the C5b--9 complex including C8 and C9. Virtually no inhibition was observed by the C5b--7 complex. C5b--9 and IgG-mediated immune suppression do not function additively. From dose-response experiments it is concluded that separate and mutually independent sites mediate suppression by C5b--9 and IgG, respectively.
与绵羊红细胞膜相关的补体C5b-9复合物，在用耶尔恩斑技术测定时，会抑制小鼠对绵羊红细胞的免疫反应。这种免疫抑制类型独立于早期补体成分和抗体，并且由人和豚鼠补体成分介导。免疫抑制程度与用于免疫的每个细胞上C5b-9复合物的数量相关：与未处理的红细胞相比，每个红细胞21,000个C5b-9复合物导致免疫反应受到97%的抑制。抑制需要C5b-9复合物的完整组装，包括C8和C9。实际上，C5b-7复合物未观察到抑制作用。C5b-9和IgG介导的免疫抑制不起相加作用。从剂量反应实验得出结论，分别由C5b-9和IgG介导抑制作用的位点是分开的且相互独立。
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