White N H, Waltman S R, Krupin T, Santiago J V
J Pediatr. 1981 Jul;99(1):41-5. doi: 10.1016/s0022-3476(81)80954-7.
Two adolescents with insulin-dependent diabetes mellitus developed unusually severe diabetic neuropathy which responded to intensive measures to achieve improved metabolic control. Employing home blood glucose monitoring and either frequent insulin injections or a portable insulin infusion pump, painful peripheral neuropathy and autonomic gastrointestinal neuropathy improved after five and 12 months of therapy, respectively. During this period of time, abnormal ocular fluorophotometry, an early change in the eye of diabetic patients, also returned to normal. These patients demonstrate the reversibility of unusually severe neuropathy and early ocular changes in adolescents with diabetes when treated with intensive measures designed to improve metabolic control.
两名胰岛素依赖型糖尿病青少年患者出现了异常严重的糖尿病神经病变，这种病变对旨在改善代谢控制的强化措施有反应。通过家庭血糖监测以及频繁注射胰岛素或使用便携式胰岛素输注泵，疼痛性周围神经病变和自主神经胃肠神经病变分别在治疗5个月和12个月后得到改善。在此期间，糖尿病患者眼部早期变化的异常眼荧光光度测定也恢复了正常。这些患者表明，采用旨在改善代谢控制的强化措施治疗时，糖尿病青少年异常严重的神经病变和早期眼部变化是可逆的。
