Spellacy W N, Tsibris A M, Tsibris J C, George S, Chez R A, O'Brien W F
Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa 33606.
Contraception. 1994 Feb;49(2):125-30. doi: 10.1016/0010-7824(94)90087-6.
The objective of the study is to evaluate the effects of a gestodene-containing oral contraceptive on carbohydrate metabolism. The design of the study is prospective. The setting is at University of South Florida Outpatient Unit. The patients consisted of twenty-three normal women desiring contraception. Serum glucose and insulin levels were measured during a three-hour glucose tolerance test at control time and after one year of drug use.
All of the one-year glucose values were significantly elevated as well as the fasting and three-hour insulin values. These changes were mostly confined to women over 26 years of age and not in the younger 18 to 23 year olds. An oral contraceptive containing 75 micrograms of gestodene and 30 micrograms of ethinylestradiol can significantly alter carbohydrate metabolism in older women.
本研究的目的是评估含孕二烯酮的口服避孕药对碳水化合物代谢的影响。本研究的设计是前瞻性的。研究地点是南佛罗里达大学门诊单元。患者包括23名希望避孕的正常女性。在对照期和用药一年后，在三小时葡萄糖耐量试验期间测量血清葡萄糖和胰岛素水平。
所有一年期的葡萄糖值以及空腹和三小时胰岛素值均显著升高。这些变化主要局限于26岁以上的女性，而18至23岁的年轻女性则没有。含有75微克孕二烯酮和30微克炔雌醇的口服避孕药可显著改变老年女性的碳水化合物代谢。
