Bowser B H, Caldwell F T, Cone J B, Eisenach K D, Thompson C H
J Trauma. 1981 Jul;21(7):558-63. doi: 10.1097/00005373-198107000-00010.
Previous studies have indicated that combining cerium nitrate with silver sulfadiazine (Silvadene, Marion Labs) yields a superior topical agent for the treatment of burns. Cerium nitrate in silver sulfadiazine was tested in a controlled study with silver sulfadiazine alone. The study population consisted of two groups of children suffering burns greater than 30% of the body surface. The patients ranged in size from 1 to 21 years. The study period was for the first 10 weeks of hospitalization. Quantitative surface cultures were used to monitor burn wound flora. No superiority for the silver sulfadiazine-cerium nitrate combination was demonstrated. In fact, cultures indicate a significantly greater percentage of Gram-negative pathogens in patients treated with the cerium mixture. Cerium nitrate could possibly prove of greatest benefit if used as a reserve therapy for colonizing organisms which do not routinely respond to silver sulfadiazine.
先前的研究表明，将硝酸铈与磺胺嘧啶银（商品名：Silvadene，Marion Labs公司生产）合用可产生一种更优的烧伤治疗外用剂。在一项对照研究中，对磺胺嘧啶银中添加硝酸铈的情况与单独使用磺胺嘧啶银进行了测试。研究对象为两组烧伤面积超过体表30%的儿童。患者年龄从1岁到21岁不等。研究期为住院的前10周。采用定量表面培养法监测烧伤创面菌群。未证明磺胺嘧啶银 - 硝酸铈组合具有优越性。事实上，培养结果表明，使用铈混合物治疗的患者中革兰氏阴性病原菌的比例显著更高。如果将硝酸铈用作对磺胺嘧啶银常规无反应的定植菌的备用疗法，可能会证明其具有最大益处。
