Brumfitt W, Hamilton-Miller J M, Ludlam H, Damjanovic V, Gargan R
Infection. 1982 Sep-Oct;10(5):280-4. doi: 10.1007/BF01640874.
Eighty-nine patients with a history of recurrent urinary infection who required immediate treatment for significant bacteriuria were treated with either trimethoprim (300 mg at night) or with the standard course of co-trimoxazole (two tablets 12-hourly) for seven days. Cure rates one week after the end of treatment were 74.4% and 80.4%, respectively. During the following month the relapse rate was lower in the group given trimethoprim than among those who had received co-trimoxazole. Consequently, the cure rates six weeks after the start of treatment were 71.4% in the trimethoprim group and 58.5% in the co-trimoxazole group. These results suggest that in this type of patient, it may be possible to reduce the incidence of bacteriological relapse by giving antibiotics in larger doses and at less frequent intervals than are at present generally recommended.
89例有复发性尿路感染病史且因严重菌尿症需要立即治疗的患者，分别接受了甲氧苄啶（每晚300毫克）或标准疗程的复方新诺明（每12小时两片）治疗，为期7天。治疗结束一周后的治愈率分别为74.4%和80.4%。在接下来的一个月里，接受甲氧苄啶治疗的组的复发率低于接受复方新诺明治疗的组。因此，治疗开始六周后的治愈率在甲氧苄啶组为71.4%，在复方新诺明组为58.5%。这些结果表明，对于这类患者，与目前普遍推荐的给药方式相比，加大抗生素剂量并减少给药频率，可能会降低细菌学复发的发生率。
