Magil A B, Wadsworth L D
Lab Invest. 1981 Jul;45(1):77-81.
Recent studies in experimental glomerulonephritis (GN) suggest that the monocyte is involved in the clearance of detritus and deposits from glomeruli. Whether this concept applies to human GN is unclear because of the paucity of studies in this area. Histochemical evaluation of more than 300 human renal biopsies disclosed eight cases of diffuse proliferative GN which demonstrated relatively large numbers of intraglomerular nonspecific esterase-positive cells. The diagnoses included GN associated with mixed essential cryoglobulinemia (three cases), diffuse lupus GN (three cases), and idiopathic diffuse proliferative GN (two cases). Electron microscopy disclosed extensive deposition of electron-dense material along glomerular basement membranes. Monocytes were present within capillary lumina, were usually associated with visible deposits, and often insinuated themselves between endothelium and the deposits so as to abut the deposits directly. The cells showed evidence of maturation (activation). The contents of the secondary lysosomes were generally similar in structure and density to neighboring deposits, especially in one case in which the deposits had an organized structure. The findings suggest that these monocytes are involved in the clearance of deposits from the glomerulus.
近期关于实验性肾小球肾炎（GN）的研究表明，单核细胞参与了肾小球中碎屑和沉积物的清除。由于该领域研究较少，尚不清楚这一概念是否适用于人类GN。对300多例人类肾活检组织进行的组织化学评估发现了8例弥漫性增殖性GN，这些病例显示肾小球内有相对大量的非特异性酯酶阳性细胞。诊断包括与混合性原发性冷球蛋白血症相关的GN（3例）、弥漫性狼疮性GN（3例）以及特发性弥漫性增殖性GN（2例）。电子显微镜检查发现沿肾小球基底膜有广泛的电子致密物质沉积。单核细胞存在于毛细血管腔内，通常与可见沉积物相关，并且常常潜入内皮细胞和沉积物之间，以便直接接触沉积物。这些细胞显示出成熟（激活）的迹象。次级溶酶体的内容物在结构和密度上通常与相邻沉积物相似，特别是在一例沉积物具有有组织结构的病例中。这些发现表明，这些单核细胞参与了肾小球沉积物的清除。
