Dudley S D, Ramirez I, Wade G N
Neuroendocrinology. 1981 Jul;33(1):7-11. doi: 10.1159/000123193.
Chronic insulin deficiency, produced by administration of 60 mg/kg streptozotocin, leads to reduced estrous behavior and lower estradiol uptake in both whole homogenate and cell nuclear fractions of hypothalamus-preoptic area and pituitary gland in ovariectomized rats. High dietary fat intake produces an ameliorative effect on both lordosis behavior and estradiol uptake, relative to animals fed a standard, carbohydrate-rich diet. Plasma glucose levels are significantly correlated with estradiol uptake levels in brain and pituitary, and with plasma radioactivity levels. The data support the hypothesis that some of the reproductive dysfunctions manifest in female diabetic rats are the result of alterations in nuclear binding of estradiol by central nervous tissue, and that chronic fuel deprivation may represent an important correlate of disruptions in normal steroid action among diabetics.
给去卵巢大鼠注射60毫克/千克链脲佐菌素所导致的慢性胰岛素缺乏，会致使下丘脑-视前区及垂体的全匀浆和细胞核组分中的动情行为减少以及雌二醇摄取降低。相对于喂食标准高碳水化合物饮食的动物，高膳食脂肪摄入对脊柱前凸行为和雌二醇摄取均产生改善作用。血浆葡萄糖水平与脑和垂体中的雌二醇摄取水平以及血浆放射性水平显著相关。这些数据支持以下假设：雌性糖尿病大鼠中出现的一些生殖功能障碍是中枢神经组织中雌二醇核结合改变的结果，并且慢性燃料缺乏可能是糖尿病患者正常类固醇作用受到干扰的一个重要相关因素。
