健康个体中低血清C2和C4水平与HLA - DW2等位基因的关联。

Association of low C2 and C4 serum levels with the HLA-DW2 allele in healthy individuals.

作者信息

Nerl C, Grosse-Wilde H, Valet G

出版信息

J Exp Med. 1978 Sep 1;148(3):704-13. doi: 10.1084/jem.148.3.704.

DOI:10.1084/jem.148.3.704

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185007/

Abstract

HLA typed unrelated healthy individuals (HLA-DW2 positive n = 64, and HLA-DW2 negative n = 72) were investigated for their C2 functional activity and C4 serum protein levels. For the C2 and C4 levels a bimodal distribution was found in HLA-DW2 positive and HLA-DW2 negative individuals. HLA-DW2 positive persons had a significantly higher incidence of low C2 and C4 serum levels. Our data support the concept that genes governing C2 as well as C4 serum levels are in linkage disequilibrium with the HLA-DW2 allele of the major histocompatibility complex.

摘要

对HLA分型的健康无关个体（HLA - DW2阳性n = 64，HLA - DW2阴性n = 72）进行了C2功能活性和C4血清蛋白水平的研究。在HLA - DW2阳性和阴性个体中，C2和C4水平呈双峰分布。HLA - DW2阳性个体中C2和C4血清低水平的发生率显著更高。我们的数据支持这样的概念，即控制C2以及C4血清水平的基因与主要组织相容性复合体的HLA - DW2等位基因处于连锁不平衡状态。

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本文引用的文献

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Hereditary deficiency of the second component of complement (C'2) in man: further observations on a second kindred.人类补体第二成分（C'2）的遗传性缺陷：对第二个家系的进一步观察。

J Immunol. 1967 Jan;98(1):72-8.

2

Structural polymorphism of the fourth component of human complement.人类补体第四成分的结构多态性

J Clin Invest. 1969 Dec;48(12):2283-92. doi: 10.1172/JCI106194.

3

Enhancement of hemolytic complement activity by treatment of human serum with iodine.用碘处理人血清增强溶血补体活性。

J Immunol. 1971 Nov;107(5):1493-5.

4

Immune hemolysis and the functional properties of the second (C2) and fourth (C4) components of complement. I. Functional differences among C4 sites on cell surfaces.免疫溶血以及补体第二成分（C2）和第四成分（C4）的功能特性。I. 细胞表面C4位点之间的功能差异。

J Immunol. 1970 Dec;105(6):1439-46.

5

Hereditary deficiency of the second component of complement (C2) in man: correlation of C2 haemolytic activity with immunochemical measurements of C2 protein.人类补体第二成分（C2）的遗传性缺陷：C2溶血活性与C2蛋白免疫化学测量的相关性。

Immunology. 1970 Jun;18(6):943-54.

6

Deficiency of the second component of complement associated with anaphylactoid purpura and presence of mycoplasma in the serum.与类过敏性紫癜相关的补体第二成分缺乏及血清中支原体的存在。

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7

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