Portha B, Giroix M H, Cros J C, Picon L
Ann Nutr Aliment. 1980;34(5-6):1143-51.
Sodium nitrite and two N-nitroso compounds, N-nitrosomethylurea (NMU) and N-nitrosomethylurethane (NMUT) have been investigated in the adult rat with regard to their in vivo effects on glucose tolerance and insulin response to glucose. Their effects have been compared to the diabetogenic action of streptozotocin (SZ). Glucose challenge (0.5 g/kg) in order to test insulin secretion in vivo gives the same result in the sodium nitrite-treated (25 mg/day during 2 months administered in drinking water) as in the control rats. In the NMU-treated (100 mg/kg i.p.) and in the NMUT-treated (100 mg/kg i.p.) glucose-induced insulin secretion tested 1 or 8 days after drug administration is severely decreased during the second test, especially in the NMUT-treated rats. Rats receiving STZ (35 mg/kg i.v.) exhibit sluggish insulin secretion as soon as the first test. Since in situ formation of nitrites and nitrosamines has been detected in human, one wonders about their role in the aetiology of human diabetes.
已在成年大鼠中研究了亚硝酸钠以及两种N-亚硝基化合物，即N-亚硝基甲基脲（NMU）和N-亚硝基甲基尿烷（NMUT）对葡萄糖耐量和胰岛素对葡萄糖反应的体内作用。已将它们的作用与链脲佐菌素（SZ）的致糖尿病作用进行了比较。为了在体内测试胰岛素分泌而进行的葡萄糖激发试验（0.5 g/kg），在亚硝酸钠处理组（在饮水中给予25 mg/天，持续2个月）和对照大鼠中产生相同的结果。在NMU处理组（腹腔注射100 mg/kg）和NMUT处理组（腹腔注射100 mg/kg）中，给药1天或8天后进行的葡萄糖诱导胰岛素分泌试验在第二次试验期间严重降低，尤其是在NMUT处理的大鼠中。接受链脲佐菌素（静脉注射35 mg/kg）的大鼠在第一次试验时就表现出胰岛素分泌迟缓。由于已在人体中检测到亚硝酸盐和亚硝胺的原位形成，人们不禁要问它们在人类糖尿病病因中的作用。
