Berney T, Kolvin I, Bhate S R, Garside R F, Jeans J, Kay B, Scarth L
Br J Psychiatry. 1981 Feb;138:110-8. doi: 10.1192/bjp.138.2.110.
A double-blind trial failed to demonstrate any significant short-term effects of clomipramine in doses recommended for use in general practice (in addition to the usual range of psychotherapeutic help) in the treatment of children with school refusal and neurotic disorder. Patterns of improvement were also studied for the sample as a whole irrespective of treatment. Neither age nor sex were significantly related to improvement, except on one behavioural measure where girls initially did better than boys. In addition, it was found that there was a rapid relief of depression but neurotic symptomatology tended to persist.
一项双盲试验未能证明，氯米帕明在全科医疗推荐剂量下（除常规心理治疗帮助外）治疗拒绝上学儿童和神经症时，有任何显著的短期效果。还对整个样本（无论治疗情况如何）的改善模式进行了研究。年龄和性别与改善情况均无显著关联，但在一项行为指标上，女孩最初比男孩表现更好。此外，研究发现抑郁症状迅速缓解，但神经症症状往往持续存在。
