百日咳疫苗研究。
Pertussis vaccine research.
作者信息
Manclark C R
出版信息
Bull World Health Organ. 1981;59(1):9-15.
The mechanisms of infection and immunity in pertussis are not well understood, and as a result, the development of a new, improved vaccine is difficult. This paper describes the limitations of currently available vaccines, and outlines the problems associated with the introduction of new prophylactics, such as defining the bases of toxicity and efficacy and organizing meaningful clinical trials. Until these problems are resolved, efforts are needed to improve currently available whole-cell vaccines. The possible role of passive immunity in the control of the disease is also discussed.
百日咳的感染和免疫机制尚未完全明确，因此，研发新型改良疫苗颇具难度。本文阐述了现有疫苗的局限性，并概述了引入新型预防措施所面临的问题，例如确定毒性和疗效的依据以及组织有意义的临床试验。在这些问题得到解决之前，需要努力改进现有的全细胞疫苗。文中还讨论了被动免疫在控制该疾病中可能发挥的作用。
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