Hulley S B, Gordon S
Circulation. 1981 Sep;64(3 Pt 2):III 57-63.
The association between reported alcohol intake and plasma high-density lipoprotein (HDL) cholesterol concentration is examined in an effort to establish whether it was a cause-and-effect basis. A cross-sectional descriptive study of several populations reveals a strong and consistent dose-response pattern: Social drinkers have mean HDL cholesterol levels that are higher than those of teetotalers by as much as 33%. Cross-sectional analyses in another epidemiological study reveal the association to be independent of potential confounding factors such as smoking and body weight, and longitudinal analyses suggest that it is also not a result of certain unmeasured sources of confounding. A small experiment reveals a 15% reduction in HDL cholesterol levels among social drinkers who abstain from alcohol from a 2-week period. The evidence supports the conclusion that alcohol habits are probably one of the determinants of plasma HDL cholesterol level. A clarification of the relevance of this phenomenon to clinical medicine awaits future clinical efforts.
研究报告的酒精摄入量与血浆高密度脂蛋白（HDL）胆固醇浓度之间的关联，以确定两者是否存在因果关系。对几个人群的横断面描述性研究揭示了一种强烈且一致的剂量反应模式：社交饮酒者的HDL胆固醇平均水平比戒酒者高出33%。另一项流行病学研究的横断面分析表明，这种关联独立于吸烟和体重等潜在混杂因素，纵向分析表明，这也不是某些未测量的混杂因素导致的结果。一项小型实验显示，在为期两周内戒酒的社交饮酒者中，HDL胆固醇水平降低了15%。证据支持这样的结论：饮酒习惯可能是血浆HDL胆固醇水平的决定因素之一。这一现象与临床医学的相关性有待未来的临床研究进一步阐明。
