Ruidavets J-B, Ducimetière P, Arveiler D, Amouyel P, Bingham A, Wagner A, Cottel D, Perret B, Ferrières J
Department of Epidemiology, INSERM U558, Faculty of Medicine, Toulouse, France.
J Epidemiol Community Health. 2002 Jan;56(1):24-8. doi: 10.1136/jech.56.1.24.
Prospective studies have shown a consistent relation between alcohol consumption and decreasing incidence of coronary artery disease. The protective effect of alcohol could be mediated through increased levels of HDL cholesterol (HDL-c). The aim of this study was to examine the relation between blood lipid levels and the consumption of different types of alcoholic beverages among 1581 men and 1535 women.
Data from representative cross sectional surveys (1994-1997) in three different regions of France were used. The consumption of the different types of alcohol was quantified using a recall method according to a typical weekly consumption.
The median daily alcohol intake was 24 g for men and 4 g for women. After adjustment for confounders, total alcohol showed a positive and significant association with HDL-c and triglycerides (TG) in both sexes. In multivariate analysis, wine was positively associated with HDL-c. Beer was positively associated with HDL-c in men and with triglycerides in men and women. When taking drinking patterns into account, wine drinkers had higher HDL-c levels than non-wine drinkers. Differences became non-significant after adjustment for confounders and particularly for socioeconomic parameters.
In a French population sample, total alcohol was positively associated with HDL-c and triglycerides. The specific influence of any particular alcoholic beverage on blood lipids was not clearly demonstrated but wine preference found in a group with higher lifestyle standards was associated with a more favourable blood lipid profile.
前瞻性研究表明,饮酒与冠状动脉疾病发病率降低之间存在持续的关联。酒精的保护作用可能通过提高高密度脂蛋白胆固醇(HDL-c)水平来介导。本研究的目的是调查1581名男性和1535名女性的血脂水平与不同类型酒精饮料消费之间的关系。
使用来自法国三个不同地区具有代表性的横断面调查(1994 - 1997年)的数据。根据典型的每周消费量,采用回忆法对不同类型酒精的消费量进行量化。
男性每日酒精摄入量中位数为24克,女性为4克。在对混杂因素进行调整后,总酒精摄入量在两性中均与HDL-c和甘油三酯(TG)呈正相关且具有显著性。在多变量分析中,葡萄酒与HDL-c呈正相关。啤酒在男性中与HDL-c呈正相关,在男性和女性中与甘油三酯呈正相关。考虑饮酒模式时,葡萄酒饮用者的HDL-c水平高于非葡萄酒饮用者。在对混杂因素尤其是社会经济参数进行调整后,差异变得不显著。
在法国人群样本中,总酒精摄入量与HDL-c和甘油三酯呈正相关。任何特定酒精饮料对血脂的具体影响未得到明确证实,但在生活方式标准较高的人群中发现的葡萄酒偏好与更有利的血脂谱相关。