Carson D J, Glasgow J F, Buchanan K D, Sloan J M
Gut. 1981 Jul;22(7):554-7. doi: 10.1136/gut.22.7.554.
Sixteen patients (aged 3.5-14.3 years) with normal jejunal mucosa, originally diagnosed as having coeliac disease at least 18 months before, were started on gluten challenge. The 'end point' of challenge was significant deterioration in jejunal mucosa morphologically and morphometrically. Studies carried out both before and after challenge included intestinal absorption of D-xylose and glucose, and release of insulin and N-terminal glucagon-like immunoreactivity (N-GLI). After gluten challenge, there were significant increases in plasma N-GLI at both 45 (P less than 0.05) and 120 minutes (P less than 0.03) after oral glucose. Significant reduction occurred in glucose absorption at 45 minutes (P less than 0.04), in one-hour D-xylose absorption (P less than 0.01) and fasting serum cholesterol (P less than 0.01). Plasma N-GLI showed significant negative correlations with D-xylose absorption (P less than 0.003) and serum cholesterol (P less than 0.004).
16名空肠黏膜正常的患者（年龄3.5 - 14.3岁），最初至少在18个月前被诊断为乳糜泻，开始进行麸质激发试验。激发试验的“终点”是空肠黏膜在形态学和形态计量学上出现显著恶化。激发试验前后进行的研究包括D - 木糖和葡萄糖的肠道吸收，以及胰岛素和N端胰高血糖素样免疫反应性（N - GLI）的释放。麸质激发试验后，口服葡萄糖后45分钟（P < 0.05）和120分钟（P < 0.03）时血浆N - GLI均显著升高。45分钟时葡萄糖吸收显著降低（P < 0.04），1小时D - 木糖吸收（P < 0.01）和空腹血清胆固醇（P < 0.01）也显著降低。血浆N - GLI与D - 木糖吸收（P < 0.003）和血清胆固醇（P < 0.004）呈显著负相关。
