Kilander A F, Dotevall G, Lindstedt G, Lundberg P A
Gut. 1984 Jun;25(6):629-35. doi: 10.1136/gut.25.6.629.
Plasma enteroglucagon was measured before and during three hours after a standard meal in 21 untreated adult patients with suspected coeliac disease who all had villous atrophy of the small intestinal mucosa and malabsorption, and in nine control subjects. In 11 of these patients the diagnosis of coeliac disease was confirmed and 10 were again investigated on a gluten free diet. The coeliac patients had higher basal (37 +/- 9 pmol/l, mean +/- SE, p less than 0.05) and postprandial (70 +/- 9 pmol/l, p less than 0.005) mean plasma enteroglucagon concentrations than the control subjects (basal 14 +/- 4 pmol/l, postprandial 25 +/- 5 pmol/l). The 10 coeliac patients on gluten free diet for five to 20 months had a basal mean plasma enteroglucagon concentration not significantly lower than before treatment (25 +/- 5 pmol/l) but significantly lower postprandial enteroglucagon concentrations than before treatment (40 +/- 7 pmol/l, p less than 0.025). Postprandial plasma enteroglucagon concentration after 90 minutes in untreated patients correlated positively to the faecal fat excretion (r = 0.58, p less than 0.02). It correlated negatively to the urinary five hour D-xylose excretion after an oral load of 165 mmol D-xylose (r = -0.71, p less than 0.01). Thus, the postprandial plasma enteroglucagon concentrations in untreated coeliac disease were related to the degree of malabsorption and they normalised during treatment with a gluten free diet.
对21名未经治疗的疑似乳糜泻成年患者（均有小肠黏膜绒毛萎缩和吸收不良）以及9名对照受试者，在标准餐后及餐后三小时内测定血浆肠高血糖素。这些患者中，11例乳糜泻诊断得到证实，10例再次接受无麸质饮食调查。乳糜泻患者的基础血浆肠高血糖素平均浓度（37±9 pmol/l，均值±标准误，p<0.05）和餐后血浆肠高血糖素平均浓度（70±9 pmol/l，p<0.005）高于对照受试者（基础值14±4 pmol/l，餐后值25±5 pmol/l）。10例接受无麸质饮食5至20个月的乳糜泻患者，基础血浆肠高血糖素平均浓度不比治疗前显著降低（25±5 pmol/l），但餐后肠高血糖素浓度比治疗前显著降低（40±7 pmol/l，p<0.025）。未经治疗患者餐后90分钟的血浆肠高血糖素浓度与粪便脂肪排泄呈正相关（r = 0.58，p<0.02），与口服165 mmol D-木糖后尿中五小时D-木糖排泄呈负相关（r = -0.71，p<0.01）。因此，未经治疗的乳糜泻患者餐后血浆肠高血糖素浓度与吸收不良程度相关，且在无麸质饮食治疗期间恢复正常。
