Landgraf R, Eversmann T, Landgraf-Leurs M M
Klin Wochenschr. 1981 Jun 1;59(11):539-43. doi: 10.1007/BF01716454.
Eleven healthy volunteers, five type I diabetics, and one type II diabetic man were examined. After an overnight fast caerulein (20 ng/kg) was injected intravenously and 60 min later an oral glucose tolerance test was performed with 100 g glucose in the normals and 25 g glucose in the diabetics. Blood pressure, pulse rate, blood glucose, serum insulin, glucagon, prolactin and growth hormone values were measured during the whole period of 240 min and compared with the same parameters in control tests in the same persons without caerulein application. None of the measured parameters were significantly influenced by caerulein. It is therefore concluded that in contrast to the stimulation of the exocrine pancreas functions of the endocrine pancreas, the pituitary gland and glucose tolerance are unchanged after caerulein.
对11名健康志愿者、5名I型糖尿病患者和1名II型糖尿病男性进行了检查。在禁食过夜后，静脉注射雨蛙素（20 ng/kg），60分钟后，正常受试者口服100 g葡萄糖，糖尿病患者口服25 g葡萄糖进行口服葡萄糖耐量试验。在240分钟的整个时间段内测量血压、脉搏率、血糖、血清胰岛素、胰高血糖素、催乳素和生长激素值，并与同一受试者在未应用雨蛙素的对照试验中的相同参数进行比较。雨蛙素对所测量的参数均无显著影响。因此得出结论，与雨蛙素刺激外分泌胰腺功能相反，其对内分泌胰腺、垂体和葡萄糖耐量无影响。
