Marco J, Hedo J A, Castillo-Olivares J, Villanueva M L
Diabetologia. 1980 Nov;19(5):418-22. doi: 10.1007/BF00281819.
The effects of exogenous and endogenous hyperglycaemia on human pancreatic polypeptide secretion have been studied. In normal subjects elevation of plasma glucose concentration by glucose infusion both depressed the basal levels of circulating human pancreatic polypeptide (by 40-50%) and consistently reduced the human pancreatic polypeptide response to the ingestion of a portion-rich meal (areas above pre-meal value: 19.5 +/- 4.1 (mean +/- SEM) vs. 9.6 +/- 2.1, p < 0.01) as well as to caerulein infusion (areas above pre-caerulein value: 8.8 +/- 2.2 vs. 4.6 +/- 1.4, P < 0.01). In diabetic subjects treated with sulphonylureas or diet (fasting plasma glucose: 166 +/- 11 mg/dl, n = 24), human pancreatic polypeptide secretion evoked by food was similar to that of 24 healthy individuals (areas above basal value: 46.6 +/- 9.9 and 33.6 +/- 3.6, respectively). In insulin dependent diabetics (fasting plasma glucose: 231 +/- 19 mg/dl, n = 21) the human pancreatic polypeptide response to the meal (area above basal value: 78.2 +/- 13.7) was significantly greater than that of the controls as well as that of the noninsulin-dependent group (P < 0.05). Since the administration of pancreatic polypeptide to man has been shown to decrease pancreatic exocrine output, postprandial human pancreatic polypeptide hypersection may contribute to the decreased exocrin function of the pancreas often found in insulin-dependent diabetics.
已经研究了外源性和内源性高血糖对人胰多肽分泌的影响。在正常受试者中，通过输注葡萄糖升高血浆葡萄糖浓度，既降低了循环中人胰多肽的基础水平（降低40 - 50%），又持续降低了人胰多肽对富含蛋白质餐食摄入的反应（餐后值以上的面积：19.5±4.1（平均值±标准误）对9.6±2.1，p<0.01）以及对蛙皮素输注的反应（蛙皮素前值以上的面积：8.8±2.2对4.6±1.4，P<0.01）。在用磺脲类药物或饮食治疗的糖尿病患者中（空腹血糖：166±11mg/dl，n = 24），食物引起的人胰多肽分泌与24名健康个体相似（基础值以上的面积：分别为46.6±9.9和33.6±3.6）。在胰岛素依赖型糖尿病患者中（空腹血糖：231±19mg/dl，n = 21），人胰多肽对餐食的反应（基础值以上的面积：78.2±13.7）显著大于对照组以及非胰岛素依赖组（P<0.05）。由于已证明向人体施用胰多肽会降低胰腺外分泌量，餐后人胰多肽分泌过多可能导致胰岛素依赖型糖尿病患者中常见的胰腺外分泌功能降低。
