Rizkalla S W, Le Bouc Y, Serog P, Apfelbaum M
Metabolism. 1981 Sep;30(9):900-7. doi: 10.1016/0026-0495(81)90069-x.
The effects of different carbohydrate intakes on insulin binding to human erythrocytes were studied in thirty nine obese and twelve normal weight subjects belonging to twelve families with a strong penetrance of obesity("family experiment"), and in nine normal weight subjects with no family or personal history of obesity or diabetes ("diet experiment"). In the "family experiment," the mean insulin binding in obese subjects was significantly lower than in control normal weight siblings and parents. This difference cannot be related to an increase in carbohydrate or caloric intakes, since there was no difference in daily food intake between the obese and the control subjects. In the "diet experiment," the volunteers were studied four times: twice with their spontaneous diet, one with a normocaloric carbohydrate rich diet and once with a normocaloric fat rich diet. Both the carbohydrate and fat rich diets resulted in a significant lowering of binding when compared to the period of spontaneous diet. In the two experiments, the decrease in binding is due to a decrease in the number of receptors per erythrocyte. The possibility of a common underlying mechanism is discussed.
在39名肥胖者和12名体重正常者中研究了不同碳水化合物摄入量对胰岛素与人红细胞结合的影响。这些肥胖者和体重正常者来自12个肥胖遗传率高的家庭（“家庭实验”），另外还对9名无肥胖或糖尿病家族史及个人史的体重正常者进行了研究（“饮食实验”）。在“家庭实验”中，肥胖者的平均胰岛素结合能力显著低于对照的体重正常的兄弟姐妹及父母。这种差异与碳水化合物或热量摄入量的增加无关，因为肥胖者与对照者的每日食物摄入量并无差异。在“饮食实验”中，对志愿者进行了4次研究：两次按其自发饮食，一次采用热量正常的高碳水化合物饮食，一次采用热量正常的高脂肪饮食。与自发饮食阶段相比，高碳水化合物饮食和高脂肪饮食均导致结合能力显著降低。在这两项实验中，结合能力的降低是由于每个红细胞上受体数量的减少。文中讨论了存在共同潜在机制的可能性。
