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Comparison of effects of quinidine and dihydroquinidine on canine heart.

作者信息

Balazs T, Herman E, Atkinson J

出版信息

J Pharm Sci. 1978 Oct;67(10):1355-7. doi: 10.1002/jps.2600671005.

DOI:10.1002/jps.2600671005
PMID:702278
Abstract

Various cardiac effects of quinidine and dihydroquinidine were tested in isolated dog hearts and in vivo in dogs. No significant differences were found in the negative inotropic, chronotropic, and dromotropic effects. Dihydroquinidine was more potent than quinidine in decreasing coronary arterial pressure.

摘要

相似文献

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Comparison of effects of quinidine and dihydroquinidine on canine heart.
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引用本文的文献

1
Absorption of quinidine and dihydroquinidine in humans.
Eur J Clin Pharmacol. 1981;21(3):195-9. doi: 10.1007/BF00627920.
2
Therapeutic drug monitoring of antiarrhythmic agents.抗心律失常药物的治疗药物监测
Clin Pharmacokinet. 1982 Mar-Apr;7(2):125-48. doi: 10.2165/00003088-198207020-00003.
3
Clinical pharmacokinetics of quinidine.奎尼丁的临床药代动力学。
Clin Pharmacokinet. 1980 Mar-Apr;5(2):150-68. doi: 10.2165/00003088-198005020-00003.
4
Pharmacokinetics of dihydroquinidine in congestive heart failure patients after intravenous quinidine administration.
Eur J Clin Pharmacol. 1979 Sep;16(2):101-5. doi: 10.1007/BF00563115.