Clinical evaluation of fluproquazone in post-operative pain. A report of double-blind comparative trials in patients after surgical interventions.

A collaborative double-blind randomized trial was carried out involving 123 hospitalized patients with moderate or severe pain following surgical interventions such as episiotomy, vaginal uterus extirpation or meniscectomy. The analgesic effect of multiple oral doses of 4-(p-fluorophenyl)-1-isopropyl-7-2(1H)-quinazolinone (fluproquazone) (100 mg) was compared with that of paracetamol (500 mg). Self-assessments were made of pain relief by the patients over a 3-day period. The results showed that fluproquazone produced at least comparable relief to paracetamol after the first dose and at the end of the overall treatment period. Furthermore, the analgesic effect of fluproquazone was significantly superior to paracetamol after a 6-h period. Over-all tolerance to multiple doses was assessed as excellent or good by all the patients receiving fluproquazone. The commonest side-effects in both treatment groups were gastrointestinal symptoms. However, the overall incidence of side-effects was lower in the fluproquazone group and those that were reported were mostly mild as compared with the paracetamol group.