• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The random transition model of the cell cycle. A critical review.

作者信息

Nelson S, Green P J

出版信息

Cancer Chemother Pharmacol. 1981;6(1):11-8. doi: 10.1007/BF00253004.

DOI:10.1007/BF00253004
PMID:7023713
Abstract

The random transition model of the cell cycle has received much attention in recent years in attempts to describe and explain variations in cell cycle times. In this review we suggest statistical procedures for fitting the model to experimental data in place of the invalid techniques currently used. However, we also argue that there have been misconceptions about criteria for quality of fit of the model, and consequent biological interpretations. Other models fit just as well, and the analyses we describe do not provide evidence for any particular biological mechanism.

摘要

相似文献

1
The random transition model of the cell cycle. A critical review.
Cancer Chemother Pharmacol. 1981;6(1):11-8. doi: 10.1007/BF00253004.
2
The distributions of cell size and generation time in a model of the cell cycle incorporating size control and random transitions.在一个包含大小控制和随机转变的细胞周期模型中细胞大小和世代时间的分布。
J Theor Biol. 1985 Mar 7;113(1):29-62. doi: 10.1016/s0022-5193(85)80074-6.
3
The time-profile of cell growth in fission yeast: model selection criteria favoring bilinear models over exponential ones.裂殖酵母中细胞生长的时间曲线：支持双线性模型而非指数模型的模型选择标准。
Theor Biol Med Model. 2006 Mar 27;3:16. doi: 10.1186/1742-4682-3-16.
4
Cell cycle variability: the oscillator model of the cell cycle yields transition probability alpha and beta type curves.细胞周期变异性：细胞周期的振荡器模型产生α型和β型转变概率曲线。
Biosystems. 1982;15(4):317-30. doi: 10.1016/0303-2647(82)90046-6.
5
An oscillator cell cycle model needs no first or second chance event.振荡细胞周期模型不需要首次或二次机会事件。
Biosystems. 1982;15(4):331-9. doi: 10.1016/0303-2647(82)90047-8.
6
Random transitions and cell cycle control.随机转变与细胞周期调控。
Prog Clin Biol Res. 1981;66 Pt A:593-601.
7
Transition probability cell cycle model. Part I--Balanced growth.
J Theor Biol. 1997 Mar 7;185(1):55-67. doi: 10.1006/jtbi.1996.0289.
8
Predicting network modules of cell cycle regulators using relative protein abundance statistics.利用相对蛋白质丰度统计预测细胞周期调节因子的网络模块
BMC Syst Biol. 2017 Feb 28;11(1):30. doi: 10.1186/s12918-017-0409-1.
9
A stochastic model of cell cycle desynchronization.细胞周期去同步的随机模型。
Math Biosci. 2010 Feb;223(2):97-104. doi: 10.1016/j.mbs.2009.11.003. Epub 2009 Nov 15.
10
How Well Does Your Phylogenetic Model Fit Your Data?你的系统发育模型与数据拟合得如何？
Syst Biol. 2019 Jan 1;68(1):157-167. doi: 10.1093/sysbio/syy066.

引用本文的文献

1
Quantitative Studies for Cell-Division Cycle Control.细胞分裂周期调控的定量研究
Front Physiol. 2019 Aug 19;10:1022. doi: 10.3389/fphys.2019.01022. eCollection 2019.
2
Quantifying the length and variance of the eukaryotic cell cycle phases by a stochastic model and dual nucleoside pulse labelling.通过随机模型和双核苷脉冲标记定量真核细胞周期各阶段的长度和变化。
PLoS Comput Biol. 2014 Jul 24;10(7):e1003616. doi: 10.1371/journal.pcbi.1003616. eCollection 2014 Jul.
3
A stochastic model of the effects of ionizing radiation on mammalian cells in vitro.

本文引用的文献

1
Variability of cell cycle times measured in vivo in embryonic chick retina by continuous labelling with BUdR.通过用溴脱氧尿苷（BUdR）连续标记法在胚胎鸡视网膜体内测量细胞周期时间的变异性。
Nature. 1979 Jul 5;280(5717):68-71. doi: 10.1038/280068a0.
2
A unifying model for the G1 period in prokaryotes and eukaryotes.原核生物和真核生物G1期的统一模型。
Nature. 1979 Jul 5;280(5717):17-9. doi: 10.1038/280017a0.
3
QUANTITATIVE CYTOCHEMICAL STUDIES ON INTERPHASE GROWTH. I. DETERMINATION OF DNA, RNA AND MASS CONTENT OF AGE DETERMINED MOUSE FIBROBLASTS IN VITRO AND OF INTERCELLULAR VARIATION IN GENERATION TIME.
Bull Math Biol. 1984;46(3):423-46. doi: 10.1007/BF02462017.
间期生长的定量细胞化学研究。I. 体外测定不同年龄小鼠成纤维细胞的DNA、RNA和质量含量以及世代时间的细胞间变异
Exp Cell Res. 1965 May;38:272-84. doi: 10.1016/0014-4827(65)90403-9.
4
VARIATIONS IN THE GENERATION TIMES OF A STRAIN OF RAT SARCOMA CELLS IN CULTURE.培养的大鼠肉瘤细胞系代时的变化
Exp Cell Res. 1965 Apr;38:75-84. doi: 10.1016/0014-4827(65)90429-5.
5
THE DISTRIBUTION AND INTERDEPENDENCE OF GENERATION TIMES OF HELA CELLS.海拉细胞代时的分布与相互依存关系
Exp Cell Res. 1964 Jul;35:415-9. doi: 10.1016/0014-4827(64)90108-9.
6
ON THE CONCEPT OF THE CELL CYCLE.论细胞周期的概念。
J Cell Comp Physiol. 1963 Oct;62:SUPPL1:143-5.
7
A 'random transition' in the cell cycle?细胞周期中的“随机转变”？
Nature. 1980 May 8;285(5760):116. doi: 10.1038/285116a0.
8
Mammalian cell cycles need two random transitions.哺乳动物细胞周期需要两个随机转变。
Cell. 1980 Feb;19(2):493-504. doi: 10.1016/0092-8674(80)90524-3.
9
A G1 rate model accounts for cell-cycle kinetics attributed to 'transition probability'.
Nature. 1980 Oct 30;287(5785):857-9. doi: 10.1038/287857a0.
10
A mathematical model of the mitotic cycle and its application to the interpretation of percentage labeled mitoses data.有丝分裂周期的数学模型及其在解释标记有丝分裂百分数数据中的应用。
J Natl Cancer Inst. 1966 Oct;37(4):443-50.