Gilbert D A
Biosystems. 1982;15(4):317-30. doi: 10.1016/0303-2647(82)90046-6.
The limit cycle concept of cell replication attributes cell cycle variability to continuous random modulation of the rates of reactions forming the intracellular control system believed to be responsible for replication processes. It is shown that this model can yield frequency histograms and both alpha and beta type accumulative distribution curves (with respect to generation times and also to cycle phases) which are of the various forms seen experimentally. The results thus provide additional support for this concept.
细胞复制的极限环概念将细胞周期变异性归因于对形成细胞内控制系统（被认为负责复制过程）的反应速率的连续随机调节。结果表明，该模型可以产生频率直方图以及α型和β型累积分布曲线（关于世代时间以及细胞周期阶段），这些曲线具有实验中观察到的各种形式。因此，这些结果为这一概念提供了额外的支持。
