Casslén B, Thorell J, Astedt B
Contraception. 1981 Apr;23(4):435-45. doi: 10.1016/0010-7824(81)90032-9.
The coexistence of two types of plasminogen activators in human uterine fluid was demonstrated. Immunologically, one was urokinase-like and the other tissue activator-like. Both activators contributed to the fibrinolytic activity of uterine fluid. Urokinase-like immunoreactivity decreased from the proliferative phase to the luteal phase and increased premenstrually. The increase in fibrinolytic activity premenstrually was ascribed mainly to an increase in concentration of the urokinase-like plasminogen activator. A much higher urokinase-like immunoreactivity was found in the uterine fluid from IUD-users than from non-users. The fibrinolytic activity of the uterine fluid, which in contrast to that of the endometrium is known to be depressed in IUD-users, was inhibited by an antiserum against the tissue activator but only weakly influenced by an antiserum against urokinase. This indicates the presence of urokinase inhibitors in the uterine fluid of IUD-users with a capacity to inhibit the enzymatic activity of the urokinase-like plasminogen activator.
已证实在人子宫液中存在两种纤溶酶原激活剂。从免疫学角度来看，一种类似尿激酶，另一种类似组织激活剂。两种激活剂都对子宫液的纤溶活性有作用。类似尿激酶的免疫反应性从增殖期到黄体期降低，在经前增加。经前纤溶活性的增加主要归因于类似尿激酶的纤溶酶原激活剂浓度的增加。在使用宫内节育器者的子宫液中发现的类似尿激酶的免疫反应性比未使用者的要高得多。与子宫内膜的纤溶活性相反，已知使用宫内节育器者子宫液的纤溶活性受到抑制，抗组织激活剂的抗血清可抑制其活性，但抗尿激酶的抗血清对其影响较弱。这表明在使用宫内节育器者的子宫液中存在尿激酶抑制剂，其具有抑制类似尿激酶的纤溶酶原激活剂酶活性的能力。
