实验性损伤期间α-巨胎蛋白与甲胎蛋白生成的分离
Dissociation of alpha-macrofetoprotein and alpha-fetoprotein production during experimental injury.
作者信息
Hudig D, Sell S, Newell L, Smuckler E A
出版信息
Lab Invest. 1979 Feb;40(2):134-9.
The concentrations of two major fetal serum proteins of the rat, alpha-macrofetoprotein (AMF) and alpha-fetoprotein (AFP) are measured following administration of croton oil, carbon tetrachloride, galactosamine or ethionine, and after partial hepatectomy. Greatly elevated serum concentrations of AMF are found after croton oil injection, following oral administration of CCl4, and after partial hepatectomy, but not after ethionine or galactosamine. Elevations of AFP occur after administration of hepatotoxic agents during the stage of restitutive proliferation and after exposure to the hepatocarcinogen ethionine, but not after croton oil. Therefore, elevations of AMF and AFP are clearly dissociated under certain conditions. In situations such as partial hepatectomy, after which elevations in both AMF and AFP occur, AMF appears before AFP. Therefore, the production of AMF and AFP appear to be under completely independent regulation in the adult.
在给大鼠注射巴豆油、四氯化碳、半乳糖胺或乙硫氨酸后，以及部分肝切除术后，测量大鼠两种主要胎儿血清蛋白α-巨胎蛋白（AMF）和甲胎蛋白（AFP）的浓度。注射巴豆油后、口服四氯化碳后以及部分肝切除术后，血清AMF浓度大幅升高，但在给予乙硫氨酸或半乳糖胺后未升高。在恢复性增殖阶段给予肝毒性药物后以及接触肝癌致癌物乙硫氨酸后，AFP会升高，但在注射巴豆油后不会升高。因此，在某些情况下，AMF和AFP的升高明显分离。在部分肝切除等情况下，AMF和AFP都会升高，且AMF先于AFP出现。因此，在成年大鼠中，AMF和AFP的产生似乎受到完全独立的调节。
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