Knepel W, Meyer D K
Endokrinologie. 1981 Jul;77(3):325-32.
The influence of cervical vagotomy on the isoprenaline-induced renin and vasopressin release was investigated in rats. Plasma vasopressin levels were measured using a specific radioimmunoassay. Bilateral vagotomy enhanced the isoprenaline-provoked vasopressin release; however, the simultaneous increase in plasma renin concentration was diminished. This effect of bilateral vagotomy on renin release could be mimicked by i.v. infusion of vasopressin into rats whose vagi remained intact. On the other hand, in Brattleboro rats with vasopressin deficiency, bilateral vagotomy did not modify renin release. We conclude that, after bilateral vagotomy, isoprenaline elevated plasma vasopressin levels, which then attenuated the concurrent renin release, substantiating that endogenous vasopressin might participate in the control of renin release.
研究了颈迷走神经切断术对异丙肾上腺素诱导的大鼠肾素和血管加压素释放的影响。采用特异性放射免疫分析法测定血浆血管加压素水平。双侧迷走神经切断术增强了异丙肾上腺素诱发的血管加压素释放；然而，血浆肾素浓度的同时升高却减弱了。双侧迷走神经切断术对肾素释放的这种作用可通过向迷走神经完整的大鼠静脉内输注血管加压素来模拟。另一方面，在血管加压素缺乏的布拉特洛维大鼠中，双侧迷走神经切断术并未改变肾素释放。我们得出结论，双侧迷走神经切断术后，异丙肾上腺素升高了血浆血管加压素水平，进而减弱了同时发生的肾素释放，证实内源性血管加压素可能参与肾素释放的调控。
