Franĕk J, Kubín V, Novák V, Bedka J
Folia Microbiol (Praha). 1981;26(3):253-9. doi: 10.1007/BF02927432.
Using fluorescein-labelled antibodies against gamma, mu and alpha chains, Ig-containing cells in palatine tonsils were studied in 120 patients. The aim of this study was to determine the most frequently repeated typical findings as regards the numbers and localisation of these cells in tonsils and to confront the data obtained with the concept that tonsils are a component of the local immunity system. The preponderance of IgG over IgA cells was confirmed, both cell types being preferentially localized in extrafollicular tissue whereas IgM was mostly found in germinal centres. Together with progressing tonsillar atrophia, the frequency of positive findings of IgM decreased, whereas the numbers of IgG and IgA cells were proportional to the amount of remaining lymphoid tissue. IgA cells were not preponderant in tonsils and their localization in the surface layer of epithelium was rather exceptional, SC antigen could not be demonstrated unequivocally and the morphological picture in germinal centres was characteristic for IgM production rather for IgA. Thus the palatine tonsils according to the content and distribution of immunocytes, correspond to the lymph node rather than to an organ involved significantly in the local antibody formation.
使用抗γ、μ和α链的荧光素标记抗体，对120例患者腭扁桃体中的含免疫球蛋白（Ig）细胞进行了研究。本研究的目的是确定这些细胞在扁桃体中的数量和定位方面最常出现的典型发现，并将所获得的数据与扁桃体是局部免疫系统组成部分这一概念进行对比。IgG细胞相对于IgA细胞占优势得到了证实，这两种细胞类型都优先定位于滤泡外组织，而IgM大多存在于生发中心。随着扁桃体萎缩的进展，IgM阳性发现的频率降低，而IgG和IgA细胞的数量与剩余淋巴组织的量成正比。IgA细胞在扁桃体中并不占优势，它们在上皮层表层的定位相当罕见，分泌片（SC）抗原无法明确证实，生发中心的形态学表现特征是产生IgM而非IgA。因此，根据免疫细胞的含量和分布，腭扁桃体与淋巴结相对应，而不是与显著参与局部抗体形成的器官相对应。
