Frang D, Götz F, Nagy Z, Gimes L, Kocsis B
Int Urol Nephrol. 1981;13(1):41-9. doi: 10.1007/BF02082070.
The factors of infective calculus formation and the conditions favoring their prevention were studied by examining in vitro the role of the most common representative of urease-producing bacteria, Proteus mirabilis. The stream of Proteus-containing urine was found to form deposits of magnesium ammonium phosphate, carbonate apatite and ammonium-urate on the glass surfaces. Application either of mandelic acid or of Gentamycin was found to reduce the production of these deposits, and their joint application proved fully preventive to their formation. Gentamycin applied in saline acidified with mandelic acid was capable of dissolving previously formed crystals. A medication of this composition is advocated for preventive use after surgery for staghorn calculi. The necessity for continuing peroral medication and specific antibacterial therapy for months is emphasized.
通过体外研究产脲酶细菌最常见的代表菌株奇异变形杆菌的作用，对感染性结石形成的因素及有利于预防的条件进行了研究。发现含奇异变形杆菌的尿液流在玻璃表面形成磷酸镁铵、碳酸磷灰石和尿酸铵沉积物。发现应用扁桃酸或庆大霉素均可减少这些沉积物的产生，且联合应用可完全预防其形成。在扁桃酸酸化的盐水中应用庆大霉素能够溶解先前形成的晶体。提倡将这种成分的药物用于鹿角形结石手术后的预防。强调了持续数月进行口服药物治疗和特异性抗菌治疗的必要性。
