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妊娠特异性β1-糖蛋白（SP1）。纯化及部分特性鉴定。

Pregnancy-specific beta 1-glycoprotein (SP1). Purification and partial characterization.

作者信息

Engvall E

出版信息

Oncodev Biol Med. 1980;1(2):113-22.

PMID:7024933
Abstract

The pregnancy-specific beta 1-glycoprotein, SP1, was purified to homogeneity from placental extract and from serum using immunoadsorbent techniques. The isolated SP1 had a molecular weight of 90,000-110,000 daltons and an amino acid and amino sugar composition typical of an acidic glycoprotein. The availability of purified SP1 will be of value in the further evaluation of the role and importance of SP1 in malignancies as well as in normal development.

摘要

妊娠特异性β1-糖蛋白（SP1）通过免疫吸附技术从胎盘提取物和血清中纯化至同质。分离出的SP1分子量为90,000 - 110,000道尔顿，具有酸性糖蛋白典型的氨基酸和氨基糖组成。纯化的SP1的可得性对于进一步评估SP1在恶性肿瘤以及正常发育中的作用和重要性将具有价值。

相似文献

1
Pregnancy-specific beta 1-glycoprotein (SP1). Purification and partial characterization.妊娠特异性β1-糖蛋白（SP1）。纯化及部分特性鉴定。
Oncodev Biol Med. 1980;1(2):113-22.
2
[Purification and chemical characterization of pregnancy-specific beta 1-glycoprotein (SP1)].[妊娠特异性β1-糖蛋白（SP1）的纯化及化学特性分析]
Hokkaido Igaku Zasshi. 1990 Jan;65(1):50-5.
3
[The purification of pregnancy specific beta 1-glycoprotein (SP1) from third trimester serum and the immunological identification of gamma-component of SP1].[从妊娠晚期血清中纯化妊娠特异性β1-糖蛋白（SP1）及SP1γ组分的免疫学鉴定]
Nihon Sanka Fujinka Gakkai Zasshi. 1984 Oct;36(10):1913-20.
4
Evidence for the presence of oncoplacental SP1-like protein in normal nonpregnant serum.
J Clin Endocrinol Metab. 1985 Jul;61(1):188-91. doi: 10.1210/jcem-61-1-188.
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Purification of pregnancy-specific beta 1-glycoprotein with a monoclonal antibody immunoadsorbent.用单克隆抗体免疫吸附剂纯化妊娠特异性β1-糖蛋白
J Immunol Methods. 1983 May 27;60(1-2):25-31. doi: 10.1016/0022-1759(83)90331-9.
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Monoclonal antibodies in analysis of oncoplacental protein SP1 in vivo and in vitro.单克隆抗体在体内和体外对癌胎盘蛋白SP1的分析中应用
Cancer Res. 1982 May;42(5):2028-33.
7
[Isolation of the specific pregnancy protein SP1 glycoprotein and the preparation of monospecific antiserum].[特异性妊娠蛋白SP1糖蛋白的分离及单特异性抗血清的制备]
Cesk Farm. 1984 May;33(3-4):115-9.
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Further evidence for syncytiotrophoblastic localization of beta 1-SP1-glycoprotein.β1-SP1-糖蛋白合体滋养层定位的进一步证据。
Basic Appl Histochem. 1980;24(3):209-12.
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[Study on the properties of pregnancy-specific beta 1-glycoprotein (SP1) in urines of pregnant women (author's transl)].孕妇尿液中妊娠特异性β1-糖蛋白（SP1）特性的研究（作者译）
Acta Obstet Gynaecol Jpn. 1981 May;33(5):612-8.
10
Monoclonal antibodies against pregnancy-specific beta 1-glycoprotein (SP1) in immunohistochemistry and radioimmunoassay.免疫组织化学和放射免疫分析中针对妊娠特异性β1-糖蛋白（SP1）的单克隆抗体。
Oncodev Biol Med. 1983;4(6):423-7.

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