Wahlström T, Heikinheimo M
Oncodev Biol Med. 1983;4(6):423-7.
Monoclonal mouse antibodies against pregnancy-specific beta-1-glycoprotein (SP1) have been studied for their suitability in immunoperoxidase staining and radioimmunoassay methodologies. These antibodies were useful in staining normal placentas, hydatidiform moles, invasive moles and choriocarcinomas. They showed good specificity, with minimal background staining, and will thus be superior to conventional polyclonal antisera in immunohistochemistry. However, the presently tested monoclonal anti-SP1 antibodies were found not to be suitable for radioimmunoassay.
针对妊娠特异性β-1-糖蛋白（SP1）的单克隆小鼠抗体已针对其在免疫过氧化物酶染色和放射免疫测定方法中的适用性进行了研究。这些抗体可用于对正常胎盘、葡萄胎、侵袭性葡萄胎和绒毛膜癌进行染色。它们具有良好的特异性，背景染色极少，因此在免疫组织化学中优于传统的多克隆抗血清。然而，目前测试的抗SP1单克隆抗体被发现不适用于放射免疫测定。
