Coid C R, Nicholson J
Placenta. 1981 Jul-Sep;2(3):187-91. doi: 10.1016/s0143-4004(81)80001-x.
The ability of three streptococcal isolates of different pathogenicity to multiply in the tissues of pregnant mice was investigated following intravenous injection. The highly pathogenic isolate multiplied most rapidly whilst the isolate of low pathogenicity showed the least rapid growth within the observation period of 24 hours. The greatest concentration of streptococci per gram of tissue was found in the placentae of mice injected with the highly pathogenic and moderately pathogenic isolates when compared with the concentration of livers and spleen. Fetal infection did not occur within 24 hours of intravenous injection of the isolates but retarded fetal growth and infection was demonstrable five days after the injection. The isolate of moderate pathogenicity infected a greater proportion of the fetuses than the isolates of low pathogenicity. It is suggested that the outcome of streptococcal infections by the ability of isolates to multiply in host tissues.
静脉注射后，研究了三种不同致病性的链球菌分离株在妊娠小鼠组织中繁殖的能力。高致病性分离株繁殖最快，而低致病性分离株在24小时的观察期内生长速度最慢。与肝脏和脾脏中的浓度相比，在注射了高致病性和中等致病性分离株的小鼠胎盘中，每克组织中的链球菌浓度最高。静脉注射分离株后24小时内未发生胎儿感染，但胎儿生长发育迟缓，注射后五天可检测到感染。中等致病性分离株感染的胎儿比例高于低致病性分离株。研究表明，链球菌感染的结果取决于分离株在宿主组织中繁殖的能力。
