成年小鼠作为早发性B族链球菌病的模型。
Adult mice as a model for early onset group B streptococcal disease.
作者信息
Wennerstrom D E, Schutt R W
出版信息
Infect Immun. 1978 Feb;19(2):741-4. doi: 10.1128/iai.19.2.741-744.1978.
Abstract
The intravenous inoculation of adult mice with virulent group B streptococci serotype Ia resulted in fulminating sepsis with extensive colonization of the lungs and kidneys. The time course of the infection lasting 24 to 40 h, extensive pulmonary colonization, and resistance of the type Ia organism to phagocytosis in the absence of specific antibody suggest that mice are an appropriate model for the study of early onset streptococcal infection of human neonates.
摘要
用毒力强的B族血清型Ia链球菌对成年小鼠进行静脉接种，可导致暴发性败血症，并在肺和肾中广泛定植。感染病程持续24至40小时，肺部广泛定植，且在缺乏特异性抗体的情况下Ia型菌株具有抗吞噬作用，这表明小鼠是研究人类新生儿早发性链球菌感染的合适模型。
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本文引用的文献
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