Bosseray N
Br J Exp Pathol. 1983 Dec;64(6):612-6.
When 15-day pregnant mice were challenged i.v. with 1 to 2 X 10(4) virulent Brucella abortus Strain 544, the bacteria were recovered from all the placental discs and spleens of the dams, as few as 5 min post-challenge. Kinetics in both organs differed greatly. In spleens, the fraction of the inoculum recovered increased from 3-20%, from 5 min-6 h post-challenge. Brucella multiplication was low from 24-72 h. In each placenta, there was first an immediate dissemination of less than 0.1% of the inoculum. Then, some brucella disappeared leaving about 20% of the placentas free of infection, the others being infected with as few as 3 Brucella CFU on average, 4-6 h post-challenge. Brucella then multiplied in colonized placentas, leading to an average of 10(4) brucella CFU per placenta at 72 h post-challenge.
给怀孕15天的小鼠静脉注射1至2×10⁴ 强毒流产布鲁氏菌544株后，在攻毒后短短5分钟，就能从所有母鼠的胎盘盘和脾脏中分离出细菌。两个器官中的细菌动态变化差异很大。在脾脏中，攻毒后5分钟至6小时，回收的接种菌比例从3%增加到20%。布鲁氏菌在24至72小时内增殖缓慢。在每个胎盘中，首先接种菌的不到0.1%会立即扩散。然后，一些布鲁氏菌消失，约20%的胎盘未受感染，其他胎盘在攻毒后4至6小时平均感染菌数低至3个CFU。之后布鲁氏菌在定植的胎盘中增殖，在攻毒后72小时每个胎盘平均有10⁴ 个CFU。
