Leary W P, Reyes A J
S Afr Med J. 1981 Sep 5;60(10):381-4.
A combination of hydrochlorothiazide 50 mg and amiloride 5 mg (HTZ + AMl) was administered twice daily for 12 weeks to 18 hypertensive patients, as a monotherapy. There was a statistically and clinically significant decrease in the mean blood pressure level throughout the treatment period. Significant steady or random changes in blood variables included decreases in chloride, magnesium and bilirubin levels and increases in sodium, calcium, phosphorus, creatinine, triglycerides, total protein, albumin, alkaline phosphatase and SGPT levels, Blood urea nitrogen values changed biphasically. Most of these statistically significant metabolic changes had no clinical relevance. The dosage problem with HTZ + AMl is discussed.
对18名高血压患者采用氢氯噻嗪50毫克和阿米洛利5毫克的组合（HTZ + AMl）进行单药治疗，每日给药两次，持续12周。在整个治疗期间，平均血压水平有统计学和临床意义的显著下降。血液变量的显著稳定或随机变化包括氯、镁和胆红素水平降低，以及钠、钙、磷、肌酐、甘油三酯、总蛋白、白蛋白、碱性磷酸酶和SGPT水平升高，血尿素氮值呈双相变化。这些具有统计学意义的代谢变化大多无临床相关性。文中讨论了HTZ + AMl的剂量问题。
