4种乙烯基单体（氯乙烯、苯乙烯、丙烯腈、丁二烯）的代谢活化作用及致突变性
Metabolic activation and mutagenicity of 4 vinylic monomers (vinyl chloride, styrene, acrylonitrile, butadiene).
作者信息
Duverger M, Lambotte M, Malvoisin E, de Meester C, Poncelet F, Mercier M
出版信息
Toxicol Eur Res. 1981 May;3(3):131-40.
The mutagenic activity and the metabolism of four vinylic monomers; vinyl chloride, styrene, acrylonitrile and butadiene are reviewed. Those chemicals are converted by the mixed function oxidases system of the endoplasmic reticulum into reactive intermediates which can interact with macromolecules within the cell. In order to examine the mutagenic activity of these compounds and their metabolites, different mutagenicity testing systems have been used: tests with S. typhimurium, E. coli, Schizosaccharomyces pombe, Saccharomyces cerevisiae, V79 Chinese Hamster cells, CHO cells, Drosophila melanogaster as well as evaluations of chromosome aberrations.
本文综述了四种乙烯基单体（氯乙烯、苯乙烯、丙烯腈和丁二烯）的致突变活性及其代谢情况。这些化学物质在内质网的混合功能氧化酶系统作用下转化为活性中间体，后者可与细胞内的大分子相互作用。为检测这些化合物及其代谢产物的致突变活性，人们使用了不同的致突变性检测系统：鼠伤寒沙门氏菌、大肠杆菌、粟酒裂殖酵母、酿酒酵母、V79中国仓鼠细胞、CHO细胞、黑腹果蝇试验以及染色体畸变评估。
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