Dzadzieva M F, Besednova N N, Snishchenko L A, Somov G P
Zh Mikrobiol Epidemiol Immunobiol. 1981 Jul(7):71-5.
Proteinolipopolysaccharide (PLPS) isolated from the causative agent of pseudotuberculosis has the properties of a protective antigen. It protects 86-90% of mice and guinea-pigs from lethal Y. pseudotuberculosis infection (20 lethal doses) and stimulates humoral and cellular immunity factors, as well as the phagocytic activity of monocytes. It is of particular importance due to the fact that in Y. pseudotuberculosis infection the system of mononuclear phagocytes plays a significant role in eliminating the causative agent from the body. The further study of PLPS with the aim of developing prophylactic preparations shows good promise.
从假结核病原体中分离出的蛋白脂多糖（PLPS）具有保护性抗原的特性。它能保护86% - 90%的小鼠和豚鼠免受致死剂量（20个致死剂量）的假结核耶尔森菌感染，并刺激体液和细胞免疫因子以及单核细胞的吞噬活性。鉴于在假结核耶尔森菌感染中，单核吞噬细胞系统在从体内清除病原体方面发挥着重要作用，PLPS的这一特性尤为重要。以开发预防性制剂为目的对PLPS进行的进一步研究显示出良好的前景。
