Besednova N N, Timchenko N F, Sidorova V E, Dzadzieva M F, Somov G P
Zh Mikrobiol Epidemiol Immunobiol. 1975 Nov(11):100-6.
Capsular substance and extracellular proteins of the causative agent of pseudotuberculosis caused in the organism of guinea pigs a specific immunological reconstruction with the accumulation in the blood of antibodies in low titres, chiefly of macroglobulin type. The blood sera of these animals failed to protect the mice from lethal pseudotuberculosis infection in experiments of passive protection. Surface antigens of pseudotuberculosis causative agents produced a sensitizing action on the guinea pig organism; this was shown in vitro with the macrophages of the abdominal cavity of these animals. Extracellular proteins decreased the completeness of phagocytosis by neutrophilic leukocytes (demonstrated in vitro with the donor blood leukocytes).
豚鼠机体中假结核致病菌的荚膜物质和细胞外蛋白引发了特异性免疫重建，血液中出现低滴度抗体，主要是巨球蛋白类型。在被动保护实验中，这些动物的血清未能保护小鼠免受致命性假结核感染。假结核致病菌的表面抗原对豚鼠机体产生致敏作用，这在体外通过这些动物腹腔巨噬细胞得到证实。细胞外蛋白降低了嗜中性白细胞吞噬作用的完整性（在体外通过供血者血液白细胞得到证实）。
