Romanenkova N I, Kleganov V K, Avdeeva T A, Chakhutinskaia M G, Vartanian Iu P
Zh Mikrobiol Epidemiol Immunobiol. 1981 Jul(7):99-103.
Feces from 249 adult patients hospitalized due to diarrhea of unknown etiology were investigated. In 65.5% of the patients enterotoxic E. coli (ETEC) producing thermostable enterotoxin were detected by the anal test in suckling mice. As demonstrated by the paw edema test in mice, 79% of such strains produced also thermolabile enterotoxin, the remaining strains belonged to the ETEC variants, known from the literature, producing only thermostable enterotoxin. The antigenic similarity of the thermolabile enterotoxin with cholerogen was confirmed by the phenomenon of paw edema neutralization in mice. Among the cultures isolated from the patients 2 ETEC variants, which could not be differentiated by the test in suckling mice and by the paw edema test in mice and paw edema neutralization, were detected by the intranasal infection of mice.
对249名因不明病因腹泻而住院的成年患者的粪便进行了调查。通过乳鼠肛门试验，在65.5%的患者中检测到产生耐热肠毒素的产肠毒素大肠杆菌（ETEC）。如小鼠爪肿胀试验所示，79%的此类菌株还产生不耐热肠毒素，其余菌株属于文献中已知的仅产生耐热肠毒素的ETEC变体。小鼠爪肿胀中和现象证实了不耐热肠毒素与霍乱毒素的抗原相似性。在从患者中分离出的培养物中，通过小鼠鼻内感染检测到2种ETEC变体，它们不能通过乳鼠试验、小鼠爪肿胀试验和爪肿胀中和试验进行区分。
