Runciman W B, Ilsley A H, Roberts J G
Anaesth Intensive Care. 1981 Aug;9(3):208-20. doi: 10.1177/0310057X8100900302.
Errors in thermodilution cardiac output measurement were quantitated to determine the order of accuracy of routine measurements performed by unskilled personnel. In vitro and in vivo studies were undertaken to examine factors affecting the volume and temperature of the injectate, catheter thermistor and computer performance, effect of respiration, use of cold (0-4 degrees C) versus ambient temperature (20-25 degrees C) injectate, and the interpretation of measurements. Ambient temperature injectate incurred unacceptably large errors; cold injectate (injections were timed with respiration) produced variations in performance by equipment and personnel which accounted for only 2% of the variation between successive measurements. Real changes in cardiac output and inherent variability of the downslope of the thermal curve, necessitating an empirically based calculation, account for up to 10% variation between successive measurements. When cold injectate was used, and the average of three corrected measurements taken, thermodilution cardiac output measurements were within 10% of a simultaneous dye dilution measurement.
对热稀释法心输出量测量中的误差进行了定量分析，以确定非专业人员进行常规测量时的准确程度顺序。开展了体外和体内研究，以考察影响注入液体积和温度、导管热敏电阻及计算机性能的因素、呼吸的影响、使用冷（0 - 4摄氏度）注入液与室温（20 - 25摄氏度）注入液的情况以及测量结果的解读。室温注入液会产生大到无法接受的误差；冷注入液（注入与呼吸同步计时）导致设备和人员的性能变化，而这仅占连续测量间变化的2%。心输出量的实际变化以及热曲线下降斜率的固有变异性需要基于经验的计算，这在连续测量间造成了高达10%的变化。当使用冷注入液并取三次校正测量的平均值时，热稀释法心输出量测量结果与同步染料稀释测量结果的偏差在10%以内。
