Hendry I A
Brain Res. 1977 Oct 7;134(2):213-23. doi: 10.1016/0006-8993(77)91068-x.
An injection of nerve growth factor (NGF) into one eye of neonatal rats results in an increase in the tyrosine hydroxylase activity of the ipsilateral superior cervical ganglion. This effect was seen maximally after the intraocular injection of a depot preparation of NGF linked to cellulose. The sympathetic neurones that innervate the eye can be identified by autoradiography after the retrograde axonal transport of either NGF or tetanus toxin labelled with [125I]iodine. It was only those cells having their terminals in the vicinity of the depot preparation. This demonstrates that NGF transported from the periphery to the cell bodies is effectively retained within the transporting cell and is not released to act on extracellular receptors within the ganglion. It is suggested that this specificity of action for NGF reaching the ganglion in this fashion is important during normal development in determining the survival of adrenergic neurones.
向新生大鼠的一只眼睛注射神经生长因子（NGF）会导致同侧颈上神经节的酪氨酸羟化酶活性增加。在眼内注射与纤维素结合的NGF长效制剂后，这种效应最为明显。在用[125I]碘标记的NGF或破伤风毒素逆行轴突运输后，通过放射自显影可以识别支配眼睛的交感神经元。只有那些终末位于长效制剂附近的细胞。这表明从外周运输到细胞体的NGF有效地保留在运输细胞内，不会释放出来作用于神经节内的细胞外受体。有人提出，以这种方式到达神经节的NGF的这种作用特异性在正常发育过程中对于确定肾上腺素能神经元的存活很重要。
