Fetner C D, Barilla D E, Townsend J, Pak C Y
J Urol. 1978 Oct;120(4):399-401. doi: 10.1016/s0022-5347(17)57198-0.
The effect of oral administration of magnesium oxide on the crystallization in urine of calcium oxalate and brushite was determined in 4 cases of recurrent calcium nephrolithiasis. Each patient was evaluated while on a constant metabolic diet before, during and after therapy with magnesium (1,000 mg. magnesium as magnesium oxide per day). During magnesium therapy urinary hydrogen ion concentration increased by approximately 0.5 unit in all 4 patients and urinary calcium increased about 50 mg. per day in 2. Urinary oxalate decreased significantly in 1 patient and urinary phosphorus was reduced in 2. The urinary activity product ratio of brushite (state of saturation) increased, owing largely to the rise in urinary hydrogen ion concentration but that of calcium oxalate was not changed significantly by magnesium treatment. Although urinary magnesium increased significantly there was no significant change in the urinary formation product ratio (limit of metastability) or the rate of crystal growth of brushite or calcium oxalate. Thus, no beneficial effect of magnesium therapy could be demonstrated in this short-term study.
在4例复发性草酸钙肾结石患者中，测定了口服氧化镁对草酸钙和透钙磷石尿液结晶的影响。在镁（每天1000毫克氧化镁形式的镁）治疗前、治疗期间和治疗后，每位患者均采用恒定代谢饮食进行评估。在镁治疗期间，所有4例患者的尿氢离子浓度均升高约0.5个单位，2例患者的尿钙每天增加约50毫克。1例患者的尿草酸盐显著降低，2例患者的尿磷降低。透钙磷石的尿活性产物比（饱和状态）增加，这主要归因于尿氢离子浓度的升高，但草酸钙的尿活性产物比未因镁治疗而发生显著变化。尽管尿镁显著增加，但透钙磷石或草酸钙的尿形成产物比（亚稳极限）或晶体生长速率均无显著变化。因此，在这项短期研究中未证明镁治疗有有益效果。
