The main function of lymphocyte is the immunological supervision which is brought about via receptor structures of the cell surface. An antigen is recognized by surface immunoglobulin of B-lymphocytes as well as by antigen-recognizing receptors of T-lymphocytes and natural killers. The regulation of lymphocyte functions if brought about via another class of receptors (Fc, C3-receptors). In immunopathological processes certain characteristics of lymphocytes surface change. These changes are manifested at the level of cell populations and clones of antigen-specific lymphocytes.