Beuscher N
Z Rheumatol. 1977 Sep-Oct;36(9-10):285-93.
The influence of a benzopyrone-preparation on the process of an experimental erysipelas in the rat, an animal model for the human rheumatoid arthritis, was studied. By plethysomometric determination of the paw volume it was shown that the swelling of the paw was significantly smaller in the benzopyrone-group than in the control-group. Furthermore it was observed that the administration of benzopyrones significantly reduced cornea-oedemas, a characteristic of the erysipelas model. The reduction of body weight, occurring during erysipelas disease, is not significantly improved by benzopyrone administration. The mortality, which is much smaller in the benzopyrone-group (30%) than in the matened control group (60%), demonstrates the good tolerance of the drug. The revealed results are described and the influence of benzopyrones on this rheumatoid disease is discussed.
研究了苯并吡喃制剂对大鼠实验性丹毒（人类类风湿性关节炎的动物模型）病程的影响。通过体积描记法测定爪体积表明，苯并吡喃组爪部肿胀明显小于对照组。此外，观察到给予苯并吡喃可显著减轻角膜水肿，这是丹毒模型的一个特征。苯并吡喃给药并未显著改善丹毒疾病期间出现的体重减轻情况。苯并吡喃组的死亡率（30%）远低于成熟对照组（60%），表明该药物耐受性良好。对所揭示的结果进行了描述，并讨论了苯并吡喃对这种类风湿性疾病的影响。
