Artemova E P, Sirota A R
Probl Endokrinol (Mosk). 1993 Jul-Aug;39(4):52-4.
Effects of adoptive transfer of T lymphocytes from normal animals (intact and in vitro pretreated with tactivin) on the expression of experimental autoimmune thyroiditis in guinea pigs were studied. Thyroiditis development was characterized by immunocompetent cell imbalance, formation of antithyroid antibodies, development of diffuse and focal lymphoid-plasmacytic infiltration in thyroid tissues. A single injection of intact T lymphocytes normalized the immunity status and significantly (by three times) reduced the lymphoid infiltration area but did not augment thyroxin secretion in animals with thyroiditis. Immunotherapy of the condition with tactivin-activated lymphocytes was found more effective, for it enhanced serum thyroxin secretion, normalized the immunity status, and reduced lymphoid-plasmacytic infiltration of the thyroid.
研究了将正常动物（完整的以及用激活素体外预处理的）的T淋巴细胞过继转移对豚鼠实验性自身免疫性甲状腺炎表达的影响。甲状腺炎的发展特征为免疫活性细胞失衡、抗甲状腺抗体的形成、甲状腺组织中弥漫性和局灶性淋巴样-浆细胞浸润的发展。单次注射完整的T淋巴细胞可使免疫状态正常化，并显著（三倍）减少淋巴浸润面积，但并未增加甲状腺炎动物的甲状腺素分泌。发现用激活素激活的淋巴细胞对该病症进行免疫治疗更有效，因为它可增强血清甲状腺素分泌、使免疫状态正常化并减少甲状腺的淋巴样-浆细胞浸润。
