Beale G H
Bull World Health Organ. 1980;58(5):799-804.
The available experimental data on the genetics of drug resistance in malaria parasites are reviewed. Seven possible mechanisms for the origin of drug resistance are considered, and it is pointed out that spontaneous gene mutation is probably the most important. Experiments on the production of pyrimethamine-resistant and chloroquine-resistant strains of rodent Plasmodium species, and on the inheritance of such drug resistance, are reviewed. Relevant biochemical data are also considered in relation to the genetics of drug resistance. Studies on competition between drug-sensitive and drug-resistant parasites in mixed populations of rodent plasmodia are described. The implications of these findings for drug resistance in P. falciparum are discussed.
本文综述了疟原虫耐药性遗传学方面现有的实验数据。文中考虑了耐药性产生的七种可能机制，并指出自发基因突变可能是最重要的。本文还综述了关于啮齿类疟原虫对乙胺嘧啶和氯喹耐药菌株的产生以及此类耐药性遗传的实验。还结合耐药性遗传学对相关生化数据进行了考量。描述了关于啮齿类疟原虫混合群体中药物敏感型和耐药型寄生虫之间竞争的研究。讨论了这些研究结果对恶性疟原虫耐药性的影响。
