Schuurman H J, Hagenaars A M, Zegers B J
Clin Chim Acta. 1977 Sep 1;79(2):363-9. doi: 10.1016/0009-8981(77)90430-2.
IgM, IgA, and AFP concentrations were determined in a group of 30 umbilical cord sera chosen at random from the cord sera sampled over a period of one year. Because low levels were expected, use was made of sensitive techniques, which were standardized on the basis of international reference preparations. Geometric mean levels were 5.58 mg/l for IgA, 142 mg/l for IgM and 53.6 mg/l for AFP. Statistical analysis of the distinct IgM, IgA, and AFP levels showed no significant correlation with either birth weight or birth length. The difference between the sexes in the levels of these proteins was not significant either. The difference between the IgA concentration in sera from children of primipara and those of multipara mothers was significant. Moreover, a statistically significant negative correlation was found between the IgA and AFP levels. The results are discussed in relation to current knowledge about the ontogeny of humoral immunity in man and a possible biological function of AFP in ontogeny.
从一年期间采集的脐带血清中随机选取30份脐带血清样本，测定其中IgM、IgA和甲胎蛋白（AFP）的浓度。鉴于预期水平较低，采用了基于国际参考制剂进行标准化的灵敏技术。IgA的几何平均水平为5.58毫克/升，IgM为142毫克/升，AFP为53.6毫克/升。对不同的IgM、IgA和AFP水平进行统计分析表明，其与出生体重或出生身长均无显著相关性。这些蛋白质水平在性别之间的差异也不显著。初产妇和经产妇所生子女血清中IgA浓度存在显著差异。此外，还发现IgA和AFP水平之间存在统计学上显著的负相关。结合目前关于人类体液免疫个体发生的知识以及AFP在个体发生中可能的生物学功能对结果进行了讨论。
