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坦桑尼亚正常体重和低体重婴儿的母-脐血对中的血清免疫球蛋白IgG、IgM和IgA

Serum immunoglobulins IgG, IgM, and IgA in maternal cord blood pairs from infants of normal and low birthweights in Tanzania.

作者信息

Boersma E R

出版信息

Arch Dis Child. 1981 Jan;56(1):31-5. doi: 10.1136/adc.56.1.31.

DOI:10.1136/adc.56.1.31
PMID:7469449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1627094/
Abstract

Serum total protein, albumin, IgG, IgM, and IgA were determined in cord blood of 54 term infants appropriate-for-gestation-age (AGA), 14 preterm AGA infants, and 21 small-for-dates infants, and in their mothers immediately after delivery in Dar-es-Salaam. The mean serum levels of total protein, albumin, and IgG in mothers who delivered a term AGA infant were 6.8 g/100 ml, 2.9 g/100 ml, and 1840 mg/100 ml respectively, whereas those from their infants were 6.9 g/100 ml, 4.1 g/100 ml, and 1471 mg/100 ml. The de novo synthesis of IgM and IgA during fetal life seems to be activated at an earlier gestational age than in infants in Western countries; this fact subsequently resulted in a higher detection rate for IgM and IgA in cord blood of term AGA infants. IgG in Tanzanian mothers was generally higher than in corresponding cord blood sera, which is contrary to the finding in Europe.

摘要

在达累斯萨拉姆,对54名足月适于胎龄(AGA)婴儿、14名早产AGA婴儿和21名小于胎龄婴儿的脐带血,以及他们母亲分娩后即刻的血清总蛋白、白蛋白、IgG、IgM和IgA进行了测定。分娩足月AGA婴儿的母亲血清总蛋白、白蛋白和IgG的平均水平分别为6.8 g/100 ml、2.9 g/100 ml和1840 mg/100 ml,而其婴儿的相应水平分别为6.9 g/100 ml、4.1 g/100 ml和1471 mg/100 ml。与西方国家的婴儿相比,胎儿期IgM和IgA的从头合成似乎在更早的孕周就被激活;这一事实随后导致足月AGA婴儿脐带血中IgM和IgA的检出率更高。坦桑尼亚母亲的IgG通常高于相应的脐带血血清,这与欧洲的研究结果相反。

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本文引用的文献

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Factors associated with low birth weight in the population of Dar es Slaaam, Tanzania.坦桑尼亚达累斯萨拉姆人口中与低出生体重相关的因素。
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