Hazel J J, Thirlwell M P, Huggins M, Maksymiuk A, MacFarlane J K
J Can Assoc Radiol. 1981 Sep;32(3):164-5.
A prospectively randomized trial in advanced gastric and pancreatic carcinoma compared multi-drug chemotherapy, with and without radiotherapy to the local lesion, in terms of median survival and toxicity. Of 29 patients with gastric adenocarcinoma, 14 were randomized to receive 5-FU and Methyl-CCNU, and 15 to receive 5-FU and local radiotherapy to a dose of 4600 rad, and then Methyl-CCNU. Thirty patients with advanced adenocarcinoma of the pancreas were similarly randomized. There was no significant difference between the two arms of the gastric or pancreatic adenocarcinoma groups, with a median survival of 13 months and 11.5 months respectively in gastric carcinoma, and 7.8 months and 7.3 months in pancreatic carcinoma. Complications were minimal in both groups. There was more hematopoietic depression in the radiation-treated patients, but none had radiotherapy discontinued because of toxicity.
一项针对晚期胃癌和胰腺癌的前瞻性随机试验，比较了多药化疗联合或不联合局部病变放疗对中位生存期和毒性的影响。29例胃腺癌患者中，14例随机接受5-氟尿嘧啶和甲基环己亚硝脲治疗，15例接受5-氟尿嘧啶及4600拉德局部放疗，随后再接受甲基环己亚硝脲治疗。30例晚期胰腺腺癌患者也进行了类似的随机分组。胃癌或胰腺癌组的两组之间无显著差异，胃癌组的中位生存期分别为13个月和11.5个月，胰腺癌组为7.8个月和7.3个月。两组的并发症均很少。放疗患者的造血抑制更明显，但无人因毒性而中断放疗。
