Laven G T, Crago S S, Kutteh W H, Mestecky J
J Immunol. 1981 Nov;127(5):1967-72.
The morphologic, histochemical, and immunohistochemical characteristics of colostral elements that form indirect IgA hemolytic plaques were determined. Microscopic examination of hemolytic plaques revealed noncellular, globular elements at the center of 82% of the plaques formed by colostral cell preparations. Similar globules in colostral cell preparations contained IgA, IgG, IgM, SC, lactoferrin, alpha-lactalbumin, and lipid. Lysates of colostral cell preparations contained large amounts (500 ng/10(6) cells) of polymeric, SC-associated IgA. These findings suggest that plaque formation by colostral cell preparations may be due to the release of passively acquired, preformed S-IgA from colostral elements, rather than active production of IgA by lymphoid cells.
对形成间接IgA溶血斑的初乳成分的形态学、组织化学和免疫组织化学特征进行了测定。对溶血斑的显微镜检查显示，在初乳细胞制剂形成的82%的斑块中心有非细胞球状成分。初乳细胞制剂中的类似小球含有IgA、IgG、IgM、分泌片（SC）、乳铁蛋白、α-乳白蛋白和脂质。初乳细胞制剂的裂解物含有大量（500 ng/10⁶细胞）与SC相关的聚合IgA。这些发现表明，初乳细胞制剂形成斑块可能是由于从初乳成分中释放出被动获得的、预先形成的分泌型IgA（S-IgA），而不是淋巴细胞主动产生IgA。
