初乳的体液成分对商陆有丝分裂原诱导的正常外周血淋巴细胞反应的抑制作用。
Inhibition of the pokeweed mitogen-induced response of normal peripheral blood lymphocytes by humoral components of colostrum.
作者信息
Crago S S, Kulhavy R, Prince S J, Mestecky J
出版信息
Clin Exp Immunol. 1981 Aug;45(2):386-92.
Abstract
Colostral whey at dilutions up to 1 : 100 inhibited both the uptake of tritium-labelled thymidine and the differentiation of pokeweed mitogen-stimulated peripheral blood lymphocytes from normal adults into immunoglobulin-containing plasma cells. Upon gel filtration (Sephadex G-200), inhibitory activity was associated with high molecular weight fractions. Secretory component, but not monomeric, polymeric or colostral IgA, IgM, IgG, lactoferrin, casein or alpha-lactalbumin, inhibited the response to mitogen. Supernatants from cultures of colostral cells did not induce the differentiation of adult peripheral or cord blood lymphocytes into IgA-containing cells and did not stimulate the uptake of tritium-labelled thymidine.
摘要
稀释至1:100的初乳乳清抑制了氚标记胸腺嘧啶核苷的摄取以及正常成年人中美洲商陆丝裂原刺激的外周血淋巴细胞向含免疫球蛋白的浆细胞的分化。在凝胶过滤（葡聚糖G - 200）时，抑制活性与高分子量组分相关。分泌成分而非单体、聚合体或初乳中的IgA、IgM、IgG、乳铁蛋白、酪蛋白或α - 乳白蛋白抑制了对丝裂原的反应。初乳细胞培养上清液不会诱导成人外周血或脐血淋巴细胞分化为含IgA的细胞，也不会刺激氚标记胸腺嘧啶核苷的摄取。
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