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1
Inhibition of the pokeweed mitogen-induced response of normal peripheral blood lymphocytes by humoral components of colostrum.初乳的体液成分对商陆有丝分裂原诱导的正常外周血淋巴细胞反应的抑制作用。
Clin Exp Immunol. 1981 Aug;45(2):386-92.
2
Hemolytic plaque formation by cellular and noncellular elements of human colostrum.人初乳的细胞和非细胞成分形成溶血空斑。
J Immunol. 1981 Nov;127(5):1967-72.
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Human colostral cells. II. Response to mitogens.人初乳细胞。II. 对有丝分裂原的反应。
Cell Immunol. 1984 Jun;86(1):222-9. doi: 10.1016/0008-8749(84)90374-5.
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Mol Immunol. 1993 Feb;30(3):277-86. doi: 10.1016/0161-5890(93)90056-h.
5
Effect of breast milk of healthy and allergic mothers on in vitro stimulation of cord blood lymphocytes.健康母亲和过敏母亲的母乳对脐血淋巴细胞体外刺激的影响。
Pediatr Allergy Immunol. 2007 Sep;18(6):486-94. doi: 10.1111/j.1399-3038.2007.00563.x. Epub 2007 Jul 25.
6
Cord blood B cell differentiation. Synergistic effect of pokeweed mitogen and Staphylococcus aureus on in vitro differentiation of B cells from human neonates.脐血B细胞分化。商陆有丝分裂原和金黄色葡萄球菌对人新生儿B细胞体外分化的协同作用。
Clin Exp Immunol. 1984 May;56(2):415-24.
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Inhibition by colostrum of the responses of peripheral blood mononuclear cells to mitogens.
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9
Immunoenzymatic determination of immunoglobulins secreted by human peripheral blood lymphocytes in pokeweed mitogen and lipo-polysaccharide stimulated cultures.免疫酶法测定人外周血淋巴细胞在商陆有丝分裂原和脂多糖刺激培养物中分泌的免疫球蛋白。
Boll Ist Sieroter Milan. 1984 Jul 31;63(3):188-95.
10
Staphylococcus aureus Cowan I-induced immunoglobulin production in human cord blood lymphocytes.金黄色葡萄球菌考恩I诱导人脐血淋巴细胞产生免疫球蛋白
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1
Hormonal influence on the secretory immune system of the eye: androgen control of secretory component production by the rat exorbital gland.激素对眼分泌免疫系统的影响：雄激素对大鼠眶外腺分泌成分产生的调控。
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2
Detection of pregnancy associated alpha 2-glycoprotein (alpha 2-PAG), an immunosuppressive agent, in IgA producing plasma cells and in body secretions.在产生IgA的浆细胞和身体分泌物中检测妊娠相关α2-糖蛋白（α2-PAG），一种免疫抑制剂。
Clin Exp Immunol. 1983 Mar;51(3):631-8.
3
Immunoinhibitory elements in human colostrum.人初乳中的免疫抑制成分。
Surv Immunol Res. 1983;2(2):164-9. doi: 10.1007/BF02918576.
4
Secretory component in breast cancer. Analysis of the levels in primary and metastatic disease.乳腺癌中的分泌成分。原发性和转移性疾病中水平的分析。
Cancer Immunol Immunother. 1985;19(3):226-30. doi: 10.1007/BF00199231.
5
Regulation of IgA synthesis and immune response by T cells and interleukins.T细胞和白细胞介素对IgA合成及免疫反应的调节
J Clin Immunol. 1989 May;9(3):175-99. doi: 10.1007/BF00916814.
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Human milk contains proteins that stimulate and suppress T lymphocyte proliferation.人乳中含有刺激和抑制T淋巴细胞增殖的蛋白质。
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7
Absorption of cytokines via oropharyngeal-associated lymphoid tissues. Does an unorthodox route improve the therapeutic index of interferon?
Clin Pharmacokinet. 1991 Dec;21(6):411-7. doi: 10.2165/00003088-199121060-00002.

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The possible induction and-or acquisition of cellular hypersensitivity associated with ingestion of colostrum.
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Proceedings: The immunologic significance of the mammary gland.会议论文集：乳腺的免疫学意义
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Recombination of the polypeptide chains of a Waldenström's IgM that binds IgG.与IgG结合的瓦尔登斯特伦巨球蛋白的多肽链重组。
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Studies on human secretory immunoglobulin A. II. Subunit structure.人类分泌型免疫球蛋白A的研究。II. 亚基结构。
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The effect of human spermatozoa on antigen and mitogen induced blastogenesis.人类精子对抗原和有丝分裂原诱导的细胞增殖的影响。
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7
Immunologic aspects of human colostrum and milk. III. Fate and absorption of cellular and soluble components in the gastrointestinal tract of the newborn.人初乳和乳汁的免疫学方面。III. 新生儿胃肠道中细胞成分和可溶性成分的命运及吸收
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In vitro studies in reproductive immunology. 1. Suppression of cell-mediated immune response by human spermatozoa and fractions isolated from human seminal plasma.
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Human colostral cells. I. Separation and characterization.人初乳细胞。I. 分离与特性鉴定。
Clin Exp Immunol. 1979 Dec;38(3):585-97.
10
Immunoregulation by breast milk cells.母乳细胞的免疫调节作用。
Cell Immunol. 1979 Feb;42(2):437-41. doi: 10.1016/0008-8749(79)90210-7.

初乳的体液成分对商陆有丝分裂原诱导的正常外周血淋巴细胞反应的抑制作用。

Inhibition of the pokeweed mitogen-induced response of normal peripheral blood lymphocytes by humoral components of colostrum.

作者信息

Crago S S, Kulhavy R, Prince S J, Mestecky J

出版信息

Clin Exp Immunol. 1981 Aug;45(2):386-92.

PMID:7318259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537390/
Abstract

Colostral whey at dilutions up to 1 : 100 inhibited both the uptake of tritium-labelled thymidine and the differentiation of pokeweed mitogen-stimulated peripheral blood lymphocytes from normal adults into immunoglobulin-containing plasma cells. Upon gel filtration (Sephadex G-200), inhibitory activity was associated with high molecular weight fractions. Secretory component, but not monomeric, polymeric or colostral IgA, IgM, IgG, lactoferrin, casein or alpha-lactalbumin, inhibited the response to mitogen. Supernatants from cultures of colostral cells did not induce the differentiation of adult peripheral or cord blood lymphocytes into IgA-containing cells and did not stimulate the uptake of tritium-labelled thymidine.

摘要

稀释至1:100的初乳乳清抑制了氚标记胸腺嘧啶核苷的摄取以及正常成年人中美洲商陆丝裂原刺激的外周血淋巴细胞向含免疫球蛋白的浆细胞的分化。在凝胶过滤（葡聚糖G - 200）时，抑制活性与高分子量组分相关。分泌成分而非单体、聚合体或初乳中的IgA、IgM、IgG、乳铁蛋白、酪蛋白或α - 乳白蛋白抑制了对丝裂原的反应。初乳细胞培养上清液不会诱导成人外周血或脐血淋巴细胞分化为含IgA的细胞，也不会刺激氚标记胸腺嘧啶核苷的摄取。