Nakamaru M, Ogihara T, Hata T, Maruyama A, Mikami H, Naka T, Iwanaga K, Kumahara Y
Jpn Circ J. 1981 Nov;45(11):1231-5. doi: 10.1253/jcj.45.1231.
The effect of age on active and cryoactivatable inactive plasma renin levels was examined in 58 normal subjects and 58 patients with essential hypertension during recumbency and after stimulation with furosemide and ambulation. Active renin levels declined with age in both supine subjects and patients. Inactive renin levels did not change with age in normal subjects, while in hypertensive patients they decreased with age. Following stimulation with furosemide and ambulation, the levels of active renin increased but its responsiveness to the stimulus decreased with age in both groups. In contrast, inactive renin was not significantly influenced by furosemide administration and ambulation. These data show that an acute stimulation with furosemide and ambulation affects mainly the active form of plasma renin, and that the effect of age on inactive plasma renin in normal subjects may be different from that in patients with essential hypertension.
在58名正常受试者和58名原发性高血压患者中，研究了年龄对卧位及使用速尿和活动刺激后活性和冷激活无活性血浆肾素水平的影响。在仰卧位的受试者和患者中，活性肾素水平均随年龄下降。在正常受试者中，无活性肾素水平不随年龄变化，而在高血压患者中，其随年龄降低。在速尿和活动刺激后，两组活性肾素水平均升高，但其对刺激的反应性随年龄降低。相比之下，速尿给药和活动对无活性肾素没有显著影响。这些数据表明，速尿和活动的急性刺激主要影响血浆肾素的活性形式，并且年龄对正常受试者无活性血浆肾素的影响可能与原发性高血压患者不同。
